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Former police detective Adrian Monk (Tony Shalhoub)
, whose photographic memory and amazing ability to piece together tiny clues made him a local legend , has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases , Monk hopes to convince his former boss
, Captain Leland Stottlemeyer (Ted Levine)

, to allow him to return to the force
. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season , is becoming more of a friend to Monk as the series develops

, frequently calling him in to help, as much for Monk's benefit as for his own. However
, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command , Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." Despite flaws and inadequacies all around , the three are becoming an increasingly effective team, with additional help from Monk's personal assistant
. From the double-episode pilot through the first half of season three
, Monk was aided by his nurse , Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard) 
. Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent
, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk , " as she still addresses her new boss.