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Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend 
, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997
. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases
, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force . Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season
, is becoming more of a friend to Monk as the series develops
, frequently calling him in to help, as much for Monk's benefit as for his own . However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator
. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford) , also seems to be developing both admiration and compassion for the man he once labeled "the defective detective ." Despite flaws and inadequacies all around
, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant . From the double-episode pilot through the first half of season three
, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season
, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy
, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr . Monk, " as she still addresses her new boss
.